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INDONESIA
Nexus Kedokteran Translasional
Published by Universitas Sebelas Maret
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
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Articles 8 Documents
 1 
Search results for , issue "Vol 1, No 1 (2012): Nexus Kedokteran Translasional" : 8 Documents clear
Pengaruh Ekstrak Daun Kemangi terhadap Penurunan Kadar Kreatinin dalam Darah Tikus Putih yang Diinduksi Parasetamol Wibowo, Arianto Adi; Ediningsih, Endang; ., Samigun
Nexus Kedokteran Translasional Vol 1, No 1 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background: Induced by parasetamol in large quantities will damaging in proximal tubule. Creatinine which should secreted by glomerolus will back in blood stream if occur kidney obstruction that which decreasing in-blood levels of creatinine. The purpose of this research is to find out whether the extract of kemangi has an effect to decrease in-blood levels of creatinine in white rats induced by parasetamol. Methods. The research was an experimental laboratoric study with the post test only controlled group design. This study was done in Setia Budi University. Subjects in this research were tirthty male white rats (Rattus norvegicus), 2-3 month of age and 150-220 gram of each weight. Subjects were divided into 5 groups.Group I as a negative control only received normal saline. Group II as a positive control  and group III, IV, and V  received parasetamol (150 mg/200 g body weight) every 3 day for 10 days. Group III received extract kemangi at 40mg / 200g body weight every 3 day for 10 days. Group IV received extract kemangi at 80mg / 200g body weight every 3 day for 10 days. Group V received extract kemangi at 120 mg 200 g body weight every 3 day for 10 days. Treatment were conducted on 11st after a 10-day adaptation. Blood sampling via plexus vena orbita of white rats for creatinine levels measured were conducted on 21st day. Then data was analyzed using One-Way ANOVA and LSD. Result. Result of One-Way ANOVA showed that there was a significant different between 5 groups: positive and negative control groups, and three dosages difference treatment (40mg, 80mg, 120mg / 200gr BB). Result of LSD showed that there was a significant different between positive control group and treatment groups; and between control group,  but there was not the significant different between negative control group and treatment groups; and each treatment groups. Conclusion. All of the extract kemangi dosages has significantly effect to decrease in- blood levels of creatinine in white rats induced by parasetamol. Statisticaly, there is no significant different in the dose diffenrence at treatment 1, 2 and 3 (40mg, 80mg, 120mg / 200gr BB). Keywords: extract kemangi, decrease in-blood levels of creatinine, parasetamol.
Perbedaan Efek Ekstrak Etanol Stevia Dibandingkan Madu Terhadap Perubahan Glukosa Darah Tikus Wistar Model Diabetik Fatimah R, Siti; ., Kisrini; Puspita Febrinasari, Ratih
Nexus Kedokteran Translasional Vol 1, No 1 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background:Stevia’s leaf contains steviol, stevioside and rebaudioside which have effect to increase secretion insulin. Honey, natural sweetener contains several antioxidant such as propolis, flavonoid and vitamin. It will eliminate free radicals and indirectly improve pankreas glands cells to produce insulin. This research was aimed to know the difference effect of stevia’s ethanol extract comparedto honey on changing of blood glucoselevel on diabetic model Wistar rats. Methods:This was experimental research with pre and post test controlled group design. Samples were 32 male rats, Wistar Strain, 6-8 weeks and + 200 gweight. Sampling technique used in this research was incidental sampling. Samples were divided into 4 groups: negative control group (aquadest), positive control (glibenclamide dose 0.09 mg/200 g body weight), treatment group 1 (stevia’s ethanol extract dose 20 mg/200 g body weight), treatment group 2 (honey dose 2 ml/200 g body weight). Data were analyze using Saphiro-Wilk’s test of normality and Friedmann test (α = 0.05) and Post Hoc Multiple Comparison (Wilcoxon) (α = 0.05) using SPSS 17 for Windows. Results:There was a significant difference (p = 0.002) on the Wistar’s blood glucose level which was given stevia’s ethanol extract or honey. Stevia’s ethanol extract effect more on decreasing the blood glucose than honey. But, the both of them are able to decrease the Wistar’s blood glucose on diabetic model Conclusions:Stevia’s ethanol extract has the effect of decreasing blood glucose level on diabetic model Wistar rats better than honey. Keywords:ethanol extract of stevia, honey, alloxan, changes in blood glucose levels.
Efek Antihiperkolesterolemia Ekstrak Buah Belimbing Wuluh (Averrhoa bilimbi Linn.) terhadap Kadar Kolesterol LDL Tikus Putih (Rattus norvegicus) Rosmalianti, Andina
Nexus Kedokteran Translasional Vol 1, No 1 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background: Current lifestyle has shifted towards high fat diet which leads to hypercholesterolemia. The increased LDL cholesterol (LDL-C) level is a risk factor for coronary heart disease. Natural plants have been increasingly used to manage metabolic diseases such as hypercholesterolemia. Among the plants is bilimbi fruit which is assumed to have anticholesterol effect owing to its bioactive components, namely pectin, saponin, and niacin. This research aims to examine the effect of bilimbi fruit extract on LDL-C levels in cholesterol-fed white rats. Methods: This was an experimental study using post test only controlled group design. A total of 35 white male Wistar rats aged 2-3 months and weighed 160-200 grams were assigned into five groups, i.e. normal control group, positive control group, negative control group, and two treatment groups with bilimbi fruit extract at dosage I and II. After being adapted for a week, all groups but normal control, were given hypercholes-terolemic food and 0,01% PTU for 14 days. At day 22, positive control group was given simvastatin 0,8 mg/200 gBW, and treatment groups were given bilimbi fruit extract at dosages of 40 mg/200 gBW and 80 mg/200 g BW, respectively for 14 days. Blood samples were taken through retro-orbital venous at day 37 to measure LDL-C levels. Data were analyzed using one way ANOVA test followed by LSD test. Results: Mean LDL-C levels differed significantly across groups (p<0,001). Results from LSD tests showed significant differences between positive control group as well as treatment groups at dosage I and II compared to negative control group (p<0,01). There were significant diferences of mean LDL-C levels between positive control group (p=0,044) and normal control group (p=0,001) compared to bilimbi fruit extract group at dosage I. No LDL-C level differences were found between bilimbi fruit extract at dosage II compared to positive control group (p=0,246) and to normal control group (p=0,790). Conclusions: Bilimbi fruit extract at dosage 40 mg/200 gBW and 80 mg/200gBW significantly decreased LDL-C levels in hypercholesterolemic white rats. Keywords: Bilimbi fruit extract, LDL-C, hypercholesterolemia
Efek Proteksi Biji Mahoni (Swietenia mahagoni Jacq.) terhadap Kerusakan Hepar Mencit yang Diinduksi Parasetamol Endahfuri, Dahniar; Listyaningsih, Endang; Sari, Yulia
Nexus Kedokteran Translasional Vol 1, No 1 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background: Seedof Swietenia mahagoni Jacq. contains alkaloids, saponins, flavonoids, triterpenoids, steroids, and tannins which were thought to protect liver from free radicals.In present study, Swietenia mahagony Jacq.seed extract was evaluated for its protective effect on paracetamol-induced liver damage in mice. Methods:To evaluate the hepatoprotective effects of Swietenia mahagony Jacq. seed extract, 28 male Swiss webster micewere equally divided into four groups. Animals of group I (K) and group II (P1) were given aquadest for 14 days. Group III (P2) received 14 mg/25 g body weight of mice of Swietenia mahagony Jacq. seed extract and the last group (P3)received 28 mg/25 g body weight of mice of Swietenia mahagony Jacq. seed extract for 14 days.Paracetamol was given to groups of P1, P2, andP3.Mice were sacrificedon the 15th day and histological preparation was made to evaluate histological damage on liver. Liver histological features were assessed by counting the number of hepatocyte on centrolobuler zone undergoing pyknosis, karyorhexis, and karyolysis. Data were analyzed using the OneWay ANOVA test (α = 0.05) and then were continued with Post Hoc Multiple Comparisons (LSD) test (α = 0.05). Results:The mean liver histological damage score was significantly higher on group of P1=60.71+7.521, whilegroup of K= 9.86+1.574 as the less.P2grouphad fewer numbers of liver histological damage (32.57+2.573) compared to the P3group(43.57+3.101). The results of OneWay ANOVA and LSD test showed that there was significant difference between the four groups (p = 0.000). Conclusions:Swietenia mahagony Jacq.seed extract showed protective effect against the hepatotoxicity induced by paracetamolin mice.Swietenia mahagony Jacq.seedextract with the dose of 14 mg/25 g bodyweight of mice showed a higher hepatoprotective effect than the dose of 28 mg/25 g body weight of mice. Keywords:Swietenia mahagony Jacq. seed, liver damage,paracetamol
Efek Proteksi Biji Mahoni (Swietenia mahagoni Jacq.) terhadap Kerusakan Hepar Mencit yang Diinduksi Parasetamol Dahniar Endahfuri; Endang Listyaningsih; Yulia Sari
Nexus Kedokteran Translasional Vol 1, No 1 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background: Seedof Swietenia mahagoni Jacq. contains alkaloids, saponins, flavonoids, triterpenoids, steroids, and tannins which were thought to protect liver from free radicals.In present study, Swietenia mahagony Jacq.seed extract was evaluated for its protective effect on paracetamol-induced liver damage in mice. Methods:To evaluate thehepatoprotectiveeffects of Swietenia mahagony Jacq. seed extract, 28 male Swiss webster micewere equallydividedinto fourgroups. Animals of group I (K) and group II (P1) were given aquadest for 14 days. Group III (P2) received 14 mg/25 g body weight of mice of Swietenia mahagony Jacq. seed extract and the last group (P3)received 28 mg/25 g body weight of mice of Swietenia mahagony Jacq. seed extract for 14 days.Paracetamol was given to groups of P1, P2, andP3.Mice were sacrificedon the 15th day and histological preparation was made to evaluate histological damage on liver. Liver histological features were assessed by counting the number of hepatocyte on centrolobuler zone undergoing pyknosis, karyorhexis, and karyolysis. Data were analyzed using the OneWay ANOVA test (? = 0.05) and then were continued with Post Hoc Multiple Comparisons (LSD) test (? = 0.05). Results:The mean liver histological damage score was significantly higher on group of P1=60.71+7.521, whilegroup of K= 9.86+1.574 as the less.P2grouphad fewer numbers of liver histological damage (32.57+2.573) compared to the P3group(43.57+3.101). The results of OneWay ANOVA and LSD test showed that there was significant difference between the four groups (p = 0.000). Conclusions:Swietenia mahagony Jacq.seed extract showed protective effect against the hepatotoxicity induced by paracetamolin mice.Swietenia mahagony Jacq.seedextract with the dose of 14 mg/25 g bodyweight of mice showed a higher hepatoprotective effect than the dose of 28 mg/25 g body weight of mice. Keywords:Swietenia mahagony Jacq. seed, liver damage,paracetamol
Perbedaan Efek Ekstrak Etanol Stevia Dibandingkan Madu Terhadap Perubahan Glukosa Darah Tikus Wistar Model Diabetik Siti Fatimah R; Kisrini .; Ratih Puspita Febrinasari
Nexus Kedokteran Translasional Vol 1, No 1 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background:Stevias leaf contains steviol, stevioside and rebaudioside which have effect to increase secretion insulin. Honey, natural sweetener contains several antioxidant such as propolis, flavonoid and vitamin. It will eliminate free radicals and indirectly improve pankreas glands cells to produce insulin. This research was aimed to know the difference effect of stevias ethanol extract comparedto honey on changing of blood glucoselevel on diabetic model Wistar rats. Methods:This was experimental research with pre and post test controlled group design. Samples were 32 male rats, Wistar Strain, 6-8 weeks and + 200 gweight. Sampling technique used in this research was incidental sampling. Samples were divided into 4 groups: negative control group (aquadest), positive control (glibenclamide dose 0.09 mg/200 g body weight), treatment group 1 (stevias ethanol extract dose 20 mg/200 g body weight), treatment group 2 (honey dose 2 ml/200 g body weight). Data were analyze using Saphiro-Wilks test of normality and Friedmann test (? = 0.05) and Post Hoc Multiple Comparison (Wilcoxon) (? = 0.05) using SPSS 17 for Windows. Results:There was a significant difference (p = 0.002) on the Wistars blood glucose level which was given stevias ethanol extract or honey. Stevias ethanol extract effect more on decreasing the blood glucose than honey. But, the both of them are able to decrease the Wistars blood glucose on diabetic model Conclusions:Stevias ethanol extract has the effect of decreasing blood glucose level on diabetic model Wistar rats better than honey. Keywords:ethanol extract of stevia, honey, alloxan, changes in blood glucose levels.
Efek Antihiperkolesterolemia Ekstrak Buah Belimbing Wuluh (Averrhoa bilimbi Linn.) terhadap Kadar Kolesterol LDL Tikus Putih (Rattus norvegicus) Andina Rosmalianti
Nexus Kedokteran Translasional Vol 1, No 1 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background: Current lifestyle has shifted towards high fat diet which leads to hypercholesterolemia. The increased LDL cholesterol (LDL-C) level is a risk factor for coronary heart disease. Natural plants have been increasingly used to manage metabolic diseases such as hypercholesterolemia. Among the plants is bilimbi fruit which is assumed to have anticholesterol effect owing to its bioactive components, namely pectin, saponin, and niacin. This research aims to examine the effect of bilimbi fruit extract on LDL-C levels in cholesterol-fed white rats. Methods: This was an experimental study using post test only controlled group design. A total of 35 white male Wistar rats aged 2-3 months and weighed 160-200 grams were assigned into five groups, i.e. normal control group, positive control group, negative control group, and two treatment groups with bilimbi fruit extract at dosage I and II. After being adapted for a week, all groups but normal control, were given hypercholes-terolemic food and 0,01% PTU for 14 days. At day 22, positive control group was given simvastatin 0,8 mg/200 gBW, and treatment groups were given bilimbi fruit extract at dosages of 40 mg/200 gBW and 80 mg/200 g BW, respectively for 14 days. Blood samples were taken through retro-orbital venous at day 37 to measure LDL-C levels. Data were analyzed using one way ANOVA test followed by LSD test. Results: Mean LDL-C levels differed significantly across groups (p<0,001). Results from LSD tests showed significant differences between positive control group as well as treatment groups at dosage I and II compared to negative control group (p<0,01). There were significant diferences of mean LDL-C levels between positive control group (p=0,044) and normal control group (p=0,001) compared to bilimbi fruit extract group at dosage I. No LDL-C level differences were found between bilimbi fruit extract at dosage II compared to positive control group (p=0,246) and to normal control group (p=0,790). Conclusions: Bilimbi fruit extract at dosage 40 mg/200 gBW and 80 mg/200gBW significantly decreased LDL-C levels in hypercholesterolemic white rats. Keywords: Bilimbi fruit extract, LDL-C, hypercholesterolemia
Pengaruh Ekstrak Daun Kemangi terhadap Penurunan Kadar Kreatinin dalam Darah Tikus Putih yang Diinduksi Parasetamol Arianto Adi Wibowo; Endang Ediningsih; Samigun .
Nexus Kedokteran Translasional Vol 1, No 1 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background: Induced by parasetamol in large quantities will damaging in proximal tubule. Creatinine which should secreted by glomerolus will back in blood stream if occur kidney obstruction that which decreasing in-blood levels of creatinine. The purpose of this research is to find out whether the extract of kemangi has an effect to decrease in-blood levels of creatinine in white rats induced by parasetamol. Methods. The research was an experimental laboratoric study with the post test only controlled group design. This study was done in Setia Budi University. Subjects in this research were tirthty male white rats (Rattus norvegicus), 2-3 month of age and 150-220 gram of each weight. Subjects were divided into 5 groups.Group I as a negative control only received normal saline. Group II as a positive control and group III, IV, and V received parasetamol (150 mg/200 g body weight) every 3 day for 10 days. Group III received extract kemangi at 40mg / 200g body weight every 3 day for 10 days. Group IV received extract kemangi at 80mg / 200g body weight every 3 day for 10 days. Group V received extract kemangi at 120 mg 200 g body weight every 3 day for 10 days. Treatment were conducted on 11st after a 10-day adaptation. Blood sampling via plexus vena orbita of white rats for creatinine levels measured were conducted on 21st day. Then data was analyzed using One-Way ANOVA and LSD. Result. Result of One-Way ANOVA showed that there was a significant different between 5 groups: positive and negative control groups, and three dosages difference treatment (40mg, 80mg, 120mg / 200gr BB). Result of LSD showed that there was a significant different between positive control group and treatment groups; and between control group, but there was not the significant different between negative control group and treatment groups; and each treatment groups. Conclusion. All of the extract kemangi dosages has significantly effect to decrease in- blood levels of creatinine in white rats induced by parasetamol. Statisticaly, there is no significant different in the dose diffenrence at treatment 1, 2 and 3 (40mg, 80mg, 120mg / 200gr BB). Keywords: extract kemangi, decrease in-blood levels of creatinine, parasetamol.

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